Forensic Medicine Identification 5a4905e9 First secondary ossification center appears in - A Lower end of femur B Upper end of humerus C Lower end of fibula D Upper end of tibia High-Yield Explanation Ossification centre appears in lower end of femur in 36 weeks.Dr. Narayana Reddys Synopsis of Forensic Medicine & Toxicology 27th edition pg. 46.