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Pathology Haematology 5a48bc20

Patients with hemophilia A has bleeding disorder because of-

A
Lack of platelet aggregation
B
Lack of reaction accelerator during activation of factor X in coagulation cascade
C
Neutralization of antithrombin III
D
Release of Thromboxane A2
High-Yield Explanation
Haemophilia is caused by quantitative reduction of factor VIII in 90% of cases well 10% cases have normal or increased level of factor VIII with reduced activity. factor VIII activates factor X the blood coagulation pathway. But in haemophilia A due to reduced activity of factor VIII ,It can not activate factor X.Therefore , no coagulation exists and increases bleeding. Reference: textbook of Pathology ,7th edition ,author Harsha Mohan, page number 313

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