Epidural anaesthesia is initiated in Primigravida at 38 weeks gestation, with a bolus of 15mg of Bupivacaine. Within few minutes, fetal heart rate monitoring shows variable decelerations. If scalp pH reveals fetal acidosis, compared with a normal pH, the anaesthetic absorbed by fetus will be present in
High-Yield Explanation
Local anaesthetics, being basic drugs become more ionized at low fetal pH. Ionized molecules are thus trapped on fetal side of circulation.