An Rh-ve woman became pregnant with a Rh+ve fetus. Within a few days after birth, the infant developed jaundice, ascites, hepatomegaly and edema. The likely substance (s) deposited in skin and sclera in jaundice is/are given below. Which is the best possible answer-

It is a case of erythroblastosis fetalis. In erythroblastosis fetalis there is excessive breakdown of RBC's. Leading to increased production of bilirubin in the blood. This increased bilirubin is predominantly unconjugated but there is some increase in conjugated bilirubin too. "The canalicular mechanisms responsible for bilirubin excretion are also immature at birth, and their maturation may lag behind that of UGT1A1, this can lead to transient conjugated neonatal hyperbilirubinemia, especially in infants with hemolysis". ---Harrison 17th/e 1928 You should also know this important fact. Hemolysis in otherwise normal individual results in purely unconjugated hyperbilirubinemia. —Harrison 1928