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Medicine General 5929904c

Which of the following is the drug of choice for the treatment of inappropriate anti-diuretic hormone secretion:

A
Frusemide
B
Hydrochlorothiazide
C
Spironolactone
D
Demeclocycline
High-Yield Explanation
Answer is D (Demeclocycline): The treatment of choice for S1APH is water restriction. The drug of choice for SIAPH (when water restriction is unsuccessful is demeclocycline). Demeclocycline (a tetracycline) acts as an ADH antagonist.

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