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Pharmacology Hypeension, Arrhythmias, Dyslipidemia 585dfd70

A patient on lithium therapy is also suffering from hypeension. Which of the following antihypeensive drugs can cause toxicity when given along with lithium to this patient ?

A
Calcium channel blockers
B
Thiazide diuretics
C
Beta blockers
D
Clonidine
High-Yield Explanation
Thiazide diuretics cause decrease sodium concentration in the body initially by acting on the DT, which inturn causes increased reabsorption of sodium as a compensatory feedback, thereby causes decreased excretion of lithium, leading to toxicity. This occurs because lithium and sodium excretion are treated in a similar fashion so increased reuptake of sodium implies that there is decreased excretion of lithium from the body leading to lithium toxicity

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