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Medicine Channelopathies and Neuropathies 5856052c

A 14-year-old boy presents with bilateral foot deformity. On examination thickened peripheral nerves and sensory gait ataxia is observed. On biopsy of the nerve, a typical onion bulb appearance is noted. The probable diagnosis is?

A
Friedreich ataxia
B
Ataxia telangiectasia
C
Charcot Marie Tooth disease
D
Leprosy
High-Yield Explanation
Image shows presence of Pes Cavus which indicates distal muscle weakness. Concomitant sensory deficit leads to Gait ataxia. Nerve biopsy: Classical onion bulb appearance s/o Charcot Marie Tooth disease. Charcot Marie Tooth disease ( Hereditary sensorimotor neuropathy) manifests as: Peroneal muscle dystrophy Stork leg appearance Thickened nerves N. biopsy: Onion bulb appearance Distal weakness ( Flexion contractures)

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