Pediatrics C.V.S. 5831ac98

Bart's hydrops fetalis is lethal because:

Hb Bart's cannot bind oxygen

The excess a-globin form insoluble precipitates

Hb Bart's cannot release oxygen to fetal tissues

Microcytic red cells become trapped in the placental

High-Yield Explanation

c. Hb Bart's cannot release oxygen to fetal tissues(Ref: Nelson's 20/e p 2349-2352, Ghai 8/e p 341)As Hb Bart's consists of 4y chains, which have very high oxygen affinity, it cannot release oxygen to fetal tissues.

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Bart's hydrops fetalis is lethal because:

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