True about fatty liver of pregnancy:a) Common in third trimesterb) Microvesicular fatty changesc) Lysosomal injury is the caused) Alcohol is the main causee) Recurrence is very common
High-Yield Explanation
Acute fatty liver of pregnancy/Acute yellow atrophy of the liver:
It is a rare condition occurring in third trimester (mean gestational age of 37.5 weeks)
It is the the M/C cause of acute liver failure during pregnancy.
Aetiology:
It is associated with disorders of fatty acid transport and oxidation-deficiency of LCHAD enzyme, i.e. long chair hydroxyl aceyl coenz A dehydrogenase
Risk is increased in case of:
First pregnancy, male fetuses, preeclampsia, maternal obesity and multiple pregnancy.
Histology: Pathology
Liver is yellow, soft and greasy: