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Pharmacology Pharmacodynamics 5820eae4

Glucagon acts via

A
cAMP
B
cGMP
C
Cytoplasmic Ca+
D
Intracellular K+
High-Yield Explanation
Ans. (a) cAMP* G-protein receptor for glucagon is Gs which acts via| Adenylyl cyclase causing |cAMP.G Proteins and Their Receptors and EffectorsG ProteinReceptors for:Effector/ Signaling PathwayGt1, Gt2Photons (rhodopsin and color opsins in retinal rod and cone cells)|cGMP phosphodiesterase- |cGMP (phototransduction)G5b-Adrenergic amines, glucagon, histamine, serotonin, and many other hormones|Adenylyl cyclase- |campGi1' Gi2' Gi3a2-Adrenergic amines, acetylcholine (muscarinic), opioids, serotonin, and many othersSeveral, including:| Adenylyl cyclase - |cAMPOpen cardiac K+ channels- | heart rateG5b-Adrenergic amines, glucagon, histamine, serotonin, and many other hormones|Adenylyl cyclase-- |cAMPGolfOdorants (olfactory epithelium)|Adenylyl cyclase- |cAMPGqAcetylcholine (muscarinic), bombesin, serotonin (5-HT1C), and many others|Phospholipase C- |IP3, diacylglycerol, cytoplasmic Ca2+

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