40 year-old immunocompromized came with C/o dysphagia. UGI scopy showed multiple ulcers in the distal esophagus. Biopsy from the esophagus showed the following. What is the diagnosis?
High-Yield Explanation
Ref. Robbins Pathology 9th edition, page. 280
Lets see it one by one
To solve -
Candida – No whitish discharge – No spore on microscopy – Ruled out
Herpes – Yes can produce multiple ulcers, but herpes will have multinucleation and groud glass eosinophilic inclusion – Ruled out
Eosinophilic esophagitis – You are not seeing classical clusters of eosinophil
CMV – intranuuclear blue inclusions – yes, immunocompromised person, yes.