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Pharmacology NSAIDs, Gout and Rheumatoid Ahritis 5698a91f

The plasma half life of aspirin:

A
Is independent of dose
B
Is longer for anti-inflammatory doses compared to that for analgesic dose
C
Is shoer for anti-inflammatory doses compared to that for analgesic dose
D
Can be increased by alkalinizing the urine
High-Yield Explanation
Aspirin and other salicylates show saturation kinetics (zero order) and thus, their half life is not constant. Clearance at high doses (anti-inflamatory) is lesser than at low (analgesic) doses. Thus t1/2 is more for anti-inflammatory dose than for analgesic dose.

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