Kamlesh, a 2 year old girl, has Down's syndrome. Her karyotype is 21/21 translocation. What is the risk ofrecurrence in subsequent pregnancies if the father is a balanced translocation carrier :

Down Syndrome– (Trisomy 21) Seen in 11n 800 to 1000 newborns M/C Nonlethal trisomy Risk of Down syndrome increases with increase in maternal age At maternal age of 35 years, the risk of having a baby with Down syndrome is 1:365. to 1:400. Recurrent Risk of Down’s syndrome