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Pathology General 55f4c8d5

All are true about neutrophil in peripheral smear examination, EXCEPT:

A
Vacuolated neutrophils may be a sign of bacterial sepsis
B
If the neutrophil granules are smaller and stain red, called toxic granules
C
The presence of neutrophils with more than five nuclear lobes suggests megaloblastic anemia
D
Large misshapen granules may reflect the inherited Chediak-Higashi syndrome.
High-Yield Explanation
Neutrophils can provide clues to a variety of conditions. Vacuolated neutrophils may be a sign of bacterial sepsis. The presence of 1- to 2-mm blue cytoplasmic inclusions, called Dohle bodies, can reflect infections, burns, or other inflammatory states. If the neutrophil granules are larger than normal and stain a darker blue, "toxic granulations" are said to be present, and they also suggest a systemic inflammation. The presence of neutrophils with more than five nuclear lobes suggests megaloblastic anemia. Large misshapen granules may reflect the inherited Chediak-Higashi syndrome.

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