Medicine General 55832aca Desmopressin nasal spray is most useful in which of the following Von Willibrand Disease? A Type 1 VWD B Type 2A VWD C Type 3 VWD D Type I & Type III High-Yield Explanation It increases the release of VWF from endothelium. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 972.