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Pharmacology JIPMER 2018 53f16396

Mechanism of action of Temozolomide is :

A
Alkylation of DNA
B
Inhibition of topoisomerase
C
Microtubule inhibition
D
Proteasome inhibition
High-Yield Explanation
Temozolomide is an alkylating agent . It is the drug of choice for brain tumors.Other alkylating agents are:* If: Ifosfamide* Bus: Busulfan* Not: Nitrosoureas* Present: Procarbazine* Take: Temozolamide* My: Mephalan, Mechlorethamaide* Cycle: CyclophosphamideTopoisomerase inhibitor is Etoposide.Microtubule inhibitors are Vincristin, Vinblastin.Proteosome inhibitors are Boezomib.

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