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Surgery General 53aa342d

Congenital cause of hypercoagulable states are all except aEUR'

A
Protein C deficiency
B
Protein S deficiency
C
MTHFR mutation
D
MTHFR mutation
High-Yield Explanation
Lupus anticoagulant [Ref: Harrison I7/e p. 7321 Causes of Hy ercoa ulable state Congenital * Factor V Leiden (5% of the population are heterozygous for FVL). * Prothrombin mutation (G202 WA, 5'UTR). * High homocysteine levels due to MTHFR mutation0 * Sickle-cell disease (only small risk) * Antithrombin III deficiency. * Protein C deficiencyQ. * Protein S deficiency0. * Plasminogen and fibrinolysis disorders (very rare) Acquired * Antiphospholipid antibodies - Anti-cardiolipin antibodies and/or - Lupus anticoagulants * Heparin-induced thrombocytopenia * Paroxysmal nocturnal hemoglobinuria * Nephrotic syndrome * Hyperestrogenemia * Estrogen-containing hormonal contraceptives * Tobacco smoking * Hyperhomocysteinemia due to vitamin I312 and folic acid deficiency.

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