A 24-year-old male presented with a swelling on anterior aspect of neck. On examination the swelling was firm and moved with deglutination. Biopsy from the lesion has been shown. What is the typical finding and diagnosis?

Ans. (b) Orphan Annie eye nuclei; papillary Ca thyroid*High power shows nuclei of papillary carcinoma cells contain finely dispersed chromatin, which imparts an optically clear or empty appearance, giving rise to the ground glass or Orphan Annie eye nuclei. In addition, invaginations of the cytoplasm may give the appearance of intranuclear inclusions ("pseudoinclusions") or intranuclear grooves. The diagnosis of papillary carcinoma can be made based on these nuclear features, even in the absence of papillary architecture.