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Pathology Kidney 5392c999

Haematuria is seen in all except:

A
IgA nephropathy
B
Alport syndrome
C
Thin basement membrane disease
D
FSGS
High-Yield Explanation
Ans: d (FSGS) Ref: Robbins, 7th ed, p. 986, 988, 999All except FSGS are causes of haematuria. The usual presentation of FSGS is proteinuria. In fact, incidence of FSGS has increased to such an extent that (both primary and secondary) it is the most common cause of nephritic syndrome in adults in united states.IgA nephropathy: (Berger disease)IgA nephropathy is a frequent cause of recurrent gross or microscopic haematuria and is the most common type of glomerulonephritis world wide.Alport syndrome:Nephritis progressing to CRF accompanied by nerve deafness and anterior lenticonus. Most common is X-linked form, females are usually carriers in whom the manifestations are typically limited to hematuria.Thin basement membrane disease:Thinning of GBM to 150-250 nm (normal is 30-400 nm). Abnormality is in genes coding alpha 3 and alpha 4 chains of type IV collagen. Most common manifestation is familial asymptomatic haematuria.

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