True regarding chronic pancreatitis is

Hereditary Pancreatitis Hereditary pancreatitis is an autosomal dominant disorder usually related to mutations of the cationic trypsinogen gene (PRSS1). Mutations in this gene cause premature activation of trypsinogen to trypsin and cause abnormalities of ductal secre- tion, both of which promote acute pancreatitis. Mutations in the SPINK1 protein, which blocks the active binding site of trypsin, is also likely to have a role in predisposing to acute pancreatitis. Variations in penetration and phenotype are common and there are many other mutations that may become implicated. Mutant enzymes activated within acinar cells can overwhelm the first line of defense (pancreatic secretory trypsin inhibitor) and resist backup defenses (e.g., proteolytic degradation, enzyme Y, and trypsin itself) allowing activated mutant cationic trypsin to trig- ger the entire zymogen activation cascade.32 Ref: schwaz's principle of surgery 10th edition Pg no :1352