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Pathology General 52a824be

A 7-year-old girl is brought with complaints of generalized swelling of the body. Urinary examination reveals grade 3 proteinuria and the presence of hyaline and fatty casts. She has no history of hematuria. Which of the following statements about her condition is true?

A
No IgG deposits or C3 deposition on renal biopsy
B
Her C3 level will be low
C
IgA nephropathy is the likely diagnosis
D
Alport's syndrome is the likely diagnosis
High-Yield Explanation
Grade 3 proteinuria, and the presence of hyaline and fatty cast in urine suggest the diagnosis of nephrotic syndrome. Most common cause of nephrotic syndrome in a child is minimal change disease ( not IgA nephropathy or Alport syndrome) In minimal change disease there is no deposition of immune reactants (immunoglobulin or complement), and serum complement levels are normal.

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