Pathology General 526dfde6 What is the defect in Dubin Johnson syndrome A Mutation in ATP7B gene B Mutation in MRP - 2 gene C Mutation in UGT1A1 gene D Mutation in ATP7A gebe High-Yield Explanation In Dubin Johnson syndrome these is impaired biliary excretion of bilirubin glucuronides due to mutation in canalicular multidrug Resistance Protein -2 (MRP- 2).