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Pharmacology Immunomodulatory: DMARDS, Monoclonal Antibodies 525b5e51

Tacrolimus level is increased by all except

A
Erythromycin
B
Itraconazole
C
Danazole
D
Rifampicin
High-Yield Explanation
Ans. (D) Rifampicinwww.medscape.com/druginfo(Ref: KDT 8/e p940, )Erythromycin, itraconazol and danazol inhibit the metabolism of tacrolimus and thus increase the plasma concentration whereas rifampicin is an enzyme inducer and decrease its plasma level.

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