Which of the following metabolic abnormality is seen with long term use of loop diuretics?

By inhibiting salt reabsorption in the TAL, loop diuretics increase delivery to the collecting duct. Increased delivery leads to increased secretion of K+ and H+ by the duct, causing hypokalemic metabolic alkalosis. This toxicity is a function of the magnitude of the diuresis and can be reversed by K+ replacement and correction of hypovolemia. Ref: Katzung, 11th edition, Chapter 15.