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Surgery General 51f13e6c

In pemphigus vulgaris, antibodies are present against:

A
Basement membrane
B
Intercellular substance
C
Cell nucleus
D
Keratin
High-Yield Explanation
In Pemphigus antibodies are directed against desmoglein (a trans membrane desmosomal glycoprotein belonging to cadherin-a calcium dependent adhesion molecule) in intercellular substance causing loss of cohesion between epidermal cells (of st. basale layer) I/t formation of acantholytic cells which can be seen on Tzank smear. .

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