Pediatrics C.V.S. 51c6e722 Best treatment for Sickle cell anemia is: A Hydroxyurea B Sulphonamide C Iron Injection D Blood transfusion High-Yield Explanation a. Hydroxyurea(Ref: Nelson's 20/e p 2236-2345', Ghai 8/e p 344-345)Hydroxyurea increases HbF levels and so is used for treatment of sickle cell anemia.