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Pharmacology Chemotherapy: General Principles 51b0fea6

All of the following cause inhibition of CYP3A except.

A
Saquinavir
B
Ritonavir
C
Itraconazole
D
Erythromycin
High-Yield Explanation
Ans. (A) Saquinavir(Ref: Katzung 11th/e p58, 863)All the drugs given in the options are microsomal enzyme inhibitors. Among protease inhibitors, ritonavir is the strongest inhibitor of CYP3A4 enzymes whereas saquinavir is the weakest.

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