Newer Influenza vaccine -a) Split-virus vaccineb) Neuraminidase c) Live attennuated vaccined) Killed vaccine

Prevention of influenza 1. Immunization Three types of vaccines are available : a) Killed vaccine - most commonly used                         b) Live attenuated - Administered as nasal drops c) Newer vaccines - Split virus vaccine (sub-virion vaccine) Used subcutaneously Recombinant vaccine Neuraminidase vaccine A trivalent, live attenuated influenza vaccine administered as a single dose intranasal spray is a effective as inactivated vaccine. It is approved for use in otherwise healthy individuals between the age of 2 years and 49 years. 2. Chemoprophylaxis Type A → Amantadine and rimantidine Both Type A & B → Zamamivir, Osteltamivir The current recommendations are that influenza A be treated with zanamivir or a combination of oseltamivir and rimantadine. Influenza B can be treated with either oseltamivir or zanamivir. For chemoprophylaxis against influenza A, Zanamivir should be used. If this is contraindicated, rimantidine should be given. For influenza B, oseltomivir is used. Following information has been added in 22nd /e of Park Oseltamivir is the drug of choice for chemoprophylaxis of influenza A (H1N1) 2009 for health care personnel’s and close contacts of suspected, probable or confirmed case of pandemic influenza A (H1N1) 2009.