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Biochemistry General 51128722

A male, 55 years old is brought to the clinic in unconscious condition. The patient is a Type 2 diabetic since 15 years. General examination reveals RBS levels 268 mg/dl. Blood and Urine samples confirm the presence of ketone bodies. Which of the following substances found raised in this patient blood is volatilized by lungs?

A
β-hydroxybutyrate
B
Acetoacetate
C
Acetone
D
Glycerol 3- phosphate
High-Yield Explanation
In most cases, ketonemia is due to increased production of ketone bodies by the liver rather than to a deficiency in their utilization by extrahepatic tissues. While acetoacetate and d(−)-3-hydroxybutyrate are readily oxidized by extrahepatic tissues, acetone is difficult to oxidize in vivo and to a large extent is volatilized in the lungs. A clear understanding of the biochemical basis and pathophysiology of DKA is essential for its efficient treatment. The cardinal biochemical features are: Hyperketonaemia (≥  3.0 mmol/L) or ketonuria (more than 2+ on standard urine sticks) Hyperglycaemia (blood glucose  ≥ 11 mmol/L, (approximately 200 mg/dL)) Metabolic acidosis (venous bicarbonate < 15 mmol/L and/or venous pH < 7.3 (H+ > 50 nmol/L)). Reference: HARPERS ILLUSTRATED BIOCHEMISTRY30th ed Page no 231; Davidson, page no 735

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