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Physiology General 50a847dd

Most of the testosterone secreted by the testes exists in the plasma in the form of ?

A
Dihydrotestosterone bound to gonadal steroid-binding hormone
B
Free dihydrotestosterone
C
Free testosterone
D
Testosterone bound to sex-steroid-binding globulin
High-Yield Explanation
The majority of circulating testosterone is bound to plasma protein (around 98%), rather than existing in free form . Of this, a majority is bound to a specific sex (or gonadal) steroid-binding protein , and a minority is bound to albumin. Dihydrotestosterone is produced from testosterone in the tissues by a specific enzyme, 5-alpha-reductase, rather than circulating in bound or free form. Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 23. Function of the Male Reproductive System. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.

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