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Pathology General 50611ff4

Human leukocyte antigen (HLA) which plays an impoant role in graft rejection is present on chromosome:

A
Sho arm of chromosome 6
B
Long arm of chromosome 6
C
Sho arm of chromosome 3
D
Long arm of chromosome 3
High-Yield Explanation
The genes for the HLA antigens are clustered in the major histocompatibility complex (MHC), located on the sho arm of chromosome 6. Three of these genes (HLA-A, HLA-B, and HLA-C) code for the class I MHC proteins. Several HLA-D loci determine the class II MHC proteins (i.e., DP, DQ, and DR). Ref: Levinson W. (2012). Chapter 62. Major Histocompatibility Complex & Transplantation. In W. Levinson (Ed), Review of Medical Microbiology & Immunology, 12e.

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