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Pathology General 503b2877

The decrease in plasma osmotic pressure is the cause of edema in?

A
CHF
B
DVT
C
Nephrotic syndrome
D
None
High-Yield Explanation
• Following conditions can cause edema :- 1) The increased hydrostatic pressure of capillaries : It causes an increase in outward driving force. It may be due to impaired venous return e.g. in CHF or DVT. 2) Decreased plasma osmotic pressure of capillaries: It causes decreases in inward driving force. It results from Hypoproteinemia. When total plasma protein is below 5 gm/dl (normal 6-8gm/dl) or albumin is below 2.5 gm/dl (normal 3.5-5 gm/dl) edema takes place. Conditions causing hypoproteinemia are a nephrotic syndrome, liver cirrhosis, protein-losing enteropathy, and PEM. 3) Defective removal of interstitial fluid by lymphatics: It is due to lymphatic obstruction, which may be inflammatory, neoplastic, post-surgical and post-irradiation.  4) Increased vascular permeability: It occurs in acute and chronic inflammation, and during angiogenesis (new vessels are leaky). 5) Sodium (salt) and water retention: It causes expansion of plasma volume (hydrostatic pressure) and dilution of plasma proteins (↓ osmotic pressure). The conditions responsible for this type of edema are ARF, acute glomerulonephritis, renal hypoperfusion, and increase renin angiotensin aldosterone system (RAAS) activity.

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