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Gynaecology & Obstetrics General 502c0732

A 15-year-old female presents with primary amenorrhea. Her breasts are normally developed but she has no axillary or public hair The most likely diagnosis is

A
turner's syndrome
B
Testicular feminization syndrome
C
Mullerian agenesis
D
Premature ovarian failure
High-Yield Explanation
Testicular feminizing syndrome Genotype is 46XY, Phenotype is female The gonads are testes often present in the inguinal canal. Gonads produce testosterone and Mullerian inhibiting substance, but because of androgen insensitivity at target organs, Patients have Lack of axillary and pubic hair and normally developed breasts Absent uterus and upper vagina May have a blind pouch of lower vagina

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