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Medicine Blood 4fef011f

An 18-year-old man is recently diagnosed with beta-thalassemia minor. His hemoglobin is 10.5 g/dL, and he feels well. Which of the following findings is characteristic of this condition?

A
an increased amount of fetal hemoglobin (HbF) or hemoglobin A2 (HbA2)
B
increased osmotic fragility of the red cells
C
absent bone marrow iron
D
increased macroglobulins in the serum
High-Yield Explanation
An increased amount of HbF or HbA2 would be expected. As beta-chains are decreased in beta-thalassemia, the excess alpha-chains combine with gamma- and delta-chains to make HbF and HbA2, respectively.

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