The preferred initial treatment for carcinoma of the anal canal is
High-Yield Explanation
#Treatment is by chemoradiotherapy in the first instance # Associated with HPV # More prevalent in patients with HIV infection # May affect the anal verge or anal canal # Lymphatic spread is to the inguinal lymph nodes # Uncommon tumour, which is usually a squamous cell carcinoma # Major ablative surgery is required if the above fails Ref: Bailey & Love&;s Sho Practice of Surgery,E25,Page-1269