Tadpole cells/comma shaped cells on histopathology are seen in -

Histology of rhabdomyosarcoma The diagnostic cell of rhabdomyosarcoma is rhabdomyoblast. Rhabdomyoblast contains eccentric eosinophilic granular cytoplasm rich in thick and thin filaments. The rhabdomyoblasts may be - Round Elongated → Tadpole or Strap cells. It has three variants Embryonal Alveolar Pleomorphic Rhabdomyoblasts are positive for desmin, MYOD1 and Myogenin.