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Pharmacology Autonomic nervous system 4f3417ae

Organophosphate sacked by inhibiting the enzyme acetylcholinesterase. Which type of enzyme inhibitors are they

A
Competitive and reversible
B
Non competitive and Irreversible
C
Uncompetitive and reversible
D
Competitive and Irreversible
High-Yield Explanation
Refer Goodman and Gilman 12e 242, Katzung 12e p106 Both organophosphates and Karbonn its cause competitive inhibition of acetylcholinesterase by binding to estaratic site. However organophosphates are Irreversible and most carbamates(except carbamyl and propoxures) are reversible inhibitors. Thus the type of inhibition of acetylcholinesterase caused by organophosphates is competitive and Irreversible

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