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Pharmacology Pancreas 4edba636

Which one of the following statements about mechanism of action of Metformin is true?

A
Stimulate glycogenolysis
B
Stimulate hepatic gluconeogenesis
C
Enhance glucose uptake by skeletal muscle
D
Release insulin from beta cells of pancreas
High-Yield Explanation
Metformin decrease blood glucose by activating AMPK (Adenosine Mono Phosphate-activated protein Kinase) that helps in Decreasing production by - Inhibiting gluconeogenesis - inhibiting glycogenolysis Increasing utilization by -Stimulation of glycolysis -Uptake of glucose by muscles and fat.

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