Levodopa is contraindicated in:-

Levo-dopa may cause mydriasis, so it is contraindicated in angle closure glaucoma. Vitamin complexes containing pyridoxine decrease the effectiveness of levo-dopa (pyridoxine is a cofactor of dopa decarboxylase and increases the formation of dopamine in the periphery. This results in decrease in l-dopa's central penetration). Abrupt withdrawal of levodopa may precipitate neuroleptic malignant syndrome. Levo-dopa should be given carefully in patients with active peptic ulcer (increased risk of bleeding) and malignant melanoma (levo-dopa is a precursor of melanin).