Not true about GIST

Currently, the term gastrointestinal stromal tumours (GISTs) is used for a group of uncommon benign tumours composed of spindle cells or stromal cells but lacking the true phenotypic features of smooth muscle cells, neural cells or Schwann cells. They are uncommon but as compared to other sites in the GIT, are most common in the stomach. Their behaviour is generally benign but may be recurrent, aggressive or even metastasis may occur. Approximately, 75-80% of all GISTs have oncogenic, gain of function mutations of the gene encoding the tyrosine kinase c-KIT TEXTBOOK OF PATHOLOGY 6TH EDITION HARSH MOHAN PAGE NO:554,555 IMAGE REF: GENERAL AND SYSTEMIC PATHOLOGY RAMDAS 2ND EDITION, FIG 13.12A AND B, PAGE :390