NADPH oxidase deficiency causes impaired immunity which of the follwoing process?

Chronic granulomatous disease is a rare, X-linked deficiency of NADPH oxidase activity which drastically impairs the ability of macrophages and neutrophils to destroy pathogens. Patients are especially vulnerable to mycobacteria, E coli, and staphylococcus since these organisms produces catalase to defend themselves against hydrogen peroxide attack by phagocytes.