All local anesthetic produces vasodilation on local application except

Cocaine is a vasoconstrictor as it is sympathomimetic. * Cocaine was the first local Anesthetic to be used clinically. IT is only natural local anesthetic. Koller introduced this in the field of ophthalmology. It is the only local anesthetic with vasoconstrictor action. It is sympathomimetic and inhibits metabolism of catecholamine. * Procaine - 1st synthetic local anesthetic. It is used primarily to reduce the pain of intramuscular injection of penicillin. * Chloroprocaine - It is shoest acting local anesthetic used for sho procedures * Benzocaine - Is a common ingredient in topical sprays, can also cause methemeglobinamia. (See complications) * Tetracaine - Also called amethocaine mostly used topically.