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Pharmacology Chemotherapy: General Principles 4db3650d

A middle aged man with chronic renal failure is diagnosed to have sputum-positive pulmonary tuberculosis. His creatinine clearance is 25 ml/min. All of the following drugs need modification in doses except:

A
Isoniazid
B
Streptomycin
C
Rifampicin
D
Ethambutol
High-Yield Explanation
Ans. (C) Rifampicin(Ref: Katzung 11/e p826, KDT 8th/e p818)Rifampicin is secreted in bile, so it does not require dose adjustment in renal failure

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