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Pediatrics General 4d920461

The finnish type of congenital nephritic syndrome occurs due to gene mutation affecting the following protein -

A
Podocin
B
Alpha-actinin
C
Nephrin
D
CD2 activated protein
High-Yield Explanation
Ans. is 'c' i.e., Nephrin Congenital nephrotic syndrome o Infant who develop nephrotic syndrome within the first 3 months of life are considered to have congenital nephrotic syndrome. o The most common cause of this syndrome is finnish-type congenital nephrotic syndrome, an autosomal recessive disorder. o Two most common genes involved are - i) NPHS1--> Coding for nephrin and results in finnish-type nephrotic syndrome. ii) NPHS2 --> Coding for Podocin and results in FSGS.

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