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Pharmacology General 4d8f5454

An antidepressant found to be associated with tardive dyskinesia and neuroleptic malignant syndrome is -

A
Fluoxetine
B
Amineptin
C
Amoxapine
D
Trazodone
High-Yield Explanation
Ans. is 'c' i.e., Amoxapine o Amoxapine is the only antidepressant which blocks D2 receptors along with inhibition of NA reuptake ----> has mixed antidepressant + neurolepic propey. o Due to blockade of D, receptors it causes extrapyramidal side effects ---> Parkinsonism, Tardive dyskinesia, Akathesia, neuropeptic malignant syndrome

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