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Pharmacology Histamine, 5-HT and PGs 4d89caf5

Which of the following adverse effects is characteristically associated with methysergide?

A
Pulmonary hypeension
B
Retroperitoneal fibrosis
C
Hepatotoxicity
D
Ischemic hea disease
High-Yield Explanation
All ergot derivatives can cause fibrosis on long term use. Due to risk of retroperitoneal fibrosis, methysergide should never be given continuously for more than 6 months.

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