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Medicine Wilson Disease 4c707201

Cirrhosis of liver with poal hypeension occurs in all except:

A
Cystic fibrosis
B
Alpha 1 anti-trypsin deficiency
C
Wilson's disease
D
Schistosomiasis
High-Yield Explanation
Schistosomiasis can lead to Poal HTN but not cirrhosis. Wilson's disease is an inherited disorder of copper homeostasis with failure to excrete excess amounts of copper, leading to its accumulation in the liver and resultant cirrhosis. Alpha 1 antitrypsin deficiency results from an inherited disorder that causes abnormal folding of the alpha-1- AT protein, resulting in failure of secretion of that protein from the liver and these patients are at greatest risk for developing chronic liver disease. Cystic fibrosis is an uncommon inherited disorder & Secondary biliary-type cirrhosis occurs in it.

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