Mouse is used for pathogenicity testing in ?

Ans. is 'c' i.e., Bordetella peussis Bordetella peussis is an obligate human parasite, but infection can be produced experimentally in several species of animals, the white mouse being most often employed. Intranasal inoculation produces a patchy interstitial pneumonia. Intraperitoneal inoculation of large doses is fatal due to toxemia. Intracerebral inoculation causes a fatal infection. Immunized mice are protected. This forms the basis for intracerebral mouse potency assay for peussis vaccines.