Sickle cell anemia is a -

Answer- c- point mutation.Sickle-cell anemia is caused by a point mutation in the b-globin chain of hemoglobin, causing the hydrophilic amino acid glutamic acid to be replaced with the hydrophobic amino acid valine at the sixth position.It is caused by a point mutation (Base substitution mutation) at the sixth position of the b-globin chain leading to subsitution of a valine residue for a glutamic acid residue resulting in sickle hemoglobin (HbS).Sickle cell anemia is an autosomal recessive disorder.