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Pathology General 4b6442a5

Chromophobe variant of Renal cell carcinoma is associated with:

A
VHL gene mutations
B
Trisomy of 7 and 17 (+7, +17)
C
3 p deletions (3p-)
D
Monosomy of 1 and Y (-1, -Y)
High-Yield Explanation
Cytogenetic examination of chromophobe RCC shows multiple and complex losses of chromosome Y, 1, 2, 6, 10, 13, 17, 21. Hypoploidy and various other chromosome losses (-1, -Y) are detectable in Chromophobe variant of Renal cell carcinoma. Ref: Harrison's Principles of Internal Medicine, 16th Edition, Page 541; Renal Cancer By Stadler, Walter, 2011, Page 263; Sternberg's Diagnostic Surgical Pathology Review By Pier Luigi DiPatre, Darryl Caer, Stephen S. Sternberg, Page 205

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